Macrolide progress

Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance.

Several macrolide-, lincosamide-, and streptogramin B-type (MLS) antibiotics were tested as inducers of erythromycin A (EM)-resistant [(14)C]leucine incorporation. Only 14-membered-ring macrolides having a glycosidically linked 6-deoxy sugar at the C-3 position of the lactone ring and the structurally dissimilar lincosamide, celesticetin, showed inducer activity. Modifications of EM at the C-4'...

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

The fall of the Macrolide: Macrolide-resistant Mycoplasma pneumoniae

Mycoplasma pneumoniae (M. pneumoniae) is a major cause of community-acquired pneumonia (CAP) in children, accounting for 10-30% of the etiological agents wor ldwide. Yet , the epidemio logy of M. pneumonia-associated CAP in Hong Kong remains unknown for several reasons. First, there is no systemic surveillance of agents causing CAP in place in Hong Kong. Secondly, serology was the mainstay of d...

The polyene macrolide antibiotics.

The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.

Kinetics of Macrolide Action

Members of the macrolide class of antibiotics inhibit peptide elongation on the ribosome by binding close to the peptidyltransferase center and blocking the peptide exit tunnel in the large ribosomal subunit. We have studied the modes of action of the macrolides josamycin, with a 16-membered lactone ring, and erythromycin, with a 14-membered lactone ring, in a cell-free mRNA translation system ...